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Results for "

transmembrane receptor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (2) Bacterial (1) CD38 (1) Endothelin Receptor (1) iGluR (2) mGluR (3) Monoamine Oxidase (1) Protease Activated Receptor (PAR) (1) Pyroptosis (1) RET (1) Smo (1) Wnt (1)
By Research Areas:	Cancer (8) Cardiovascular Disease (4) Infection (1) Inflammation/Immunology (2) Metabolic Disease (1) Neurological Disease (7)

Inhibitors & Agonists

Screening Libraries

Peptides

Inhibitory Antibodies

Recombinant Proteins

Antibodies

Targets Recommended: CFTR Enteropeptidase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-108707

LY3130481 1 Publications Verification	iGluR	Neurological Disease
LY3130481 is an AMPA receptor antagonist that is dependent upon transmembrane AMPA receptor regulatory protein (TARP) γ-8, selective inhibits AMPA/TARP γ-8 with an IC₅₀ of 65 nM .

HY-P0204A

Endothelin-3, human, mouse, rabbit, rat TFA 1 Publications Verification Endothelin 3 (Rat,Human) (TFA)	Endothelin Receptor	Cardiovascular Disease Neurological Disease
Endothelin-3, human, mouse, rabbit, rat TFA is a 21-amino acid vasoactive peptide that binds to G-protein-linked transmembrane receptors, ET-RA and ET-RB.

HY-114456

Ganglioside GM3	Others	Metabolic Disease
Ganglioside GM3 is a precursor of a-, b-, and c-series gangliosides, interacts with transmembrane receptors such as the epidermal growth factor and insulin receptors, and regulates receptor functions by creating a specialized lipid environment. Ganglioside GM3 is synthesized by GM3 synthase and can be used for the research of hypercholesterolemia .

HY-143546

RET-IN-9	RET	Cancer
RET-IN-9 is a potent inhibitor of RET. RET kinase is a single-pass transmembrane receptor tyrosine kinase that plays an important role in the development of the kidney and enteric nervous system, and the maintenance of homeostasis in the nervous, endocrine, hematopoietic, and male reproductive systems. RET-IN-9 has the potential for the research of RET-related disease including non-small cell lung cancer and medullary thyroid cancer (extracted from patent WO2021115457A1, compound 29) .

HY-123504

ML344

Bacterial Infection

ML344 is an agonist of Vibrio cholerae CqsS, a transmembrane receptor .

ML344	Bacterial	Infection
ML344 is an agonist of Vibrio cholerae CqsS, a transmembrane receptor .

HY-156095

F7H	Wnt	Cancer
F7H is a Frizzled receptor FZD7 antagonist (IC₅₀: 1.25 μM). Frizzled receptors (FZDs) influence Wnt signaling, mediating embryonic development and tissue homeostasis. F7H is a potent ligand for the FZD7 transmembrane domain (TMD) .

HY-108507

MRT-10	Smo	Cancer
MRT-10 is a seven-transmembrane receptor smoothened (Smo) antagonist with an IC₅₀ of 0.65 μM in the micromolar range in various Hedgehog (Hh) assays. MRT-10 binds to the Smo receptor at the level of the Bodipycyclopamine binding site. MRT-10 can be used for the research of cancer .

HY-111163

NSC49652	Apoptosis	Cancer
NSC49652 is a reversible, orally active p75 neurotrophin receptor (p75 ^NTR, also known as NGFR, TNFRSF16, and CD271) agonist. NSC49652 targets the transmembrane domain of p75 ^NTR. NSC49652 induces apoptosis and affects the viability of melanoma cells .

HY-P3496

Pep19-2.5	Pyroptosis	Inflammation/Immunology
Pep19-2.5 is an synthetic and antitoxin peptide, blocks the intracellular endotoxin signaling cascade. Pep19-2.5 inhibits signaling of lipopeptides (LP) and lipopolysaccharides (LPS) mediated by transmembrane and cytosolic pattern recognition receptors (PRRs). The signaling cascades lead to inflammation and cell pyroptosis .

HY-107506

Ro 67-4853	mGluR	Neurological Disease
Ro 67-4853 is a positive allosteric modulator (PAM) of mGluR1 (pEC₅₀=7.16 for rmGlu1a receptor). Ro67-4853 exhibits activity at all group I mGlu receptors including hmGlu1, rmGlu1, and rmGlu5. Ro 67-4853 enhances the potency of L-Glu by interacting with the transmembrane domain (TMD) of the receptor. Ro 67-4853 potentiates sensory synaptic responses to repetitive vibrissa stimulation .

HY-103565

AMN082	mGluR	Neurological Disease
AMN082, a selective, orally active, and brain penetrant mGluR7 agonist, directly activates receptor signaling via an allosteric site in the transmembrane domain. AMN082 potently inhibits cAMP accumulation and stimulates GTPγS binding (EC₅₀ values, 64-290 nM) at transfected mammalian cells expressing mGluR7. AMN082 shows selectivity over other mGluR subtypes and selected ionotropic glutamate receptors. Antidepressant effects .

HY-117833

PXS-4681A	Monoamine Oxidase	Inflammation/Immunology
PXS-4681A is a potent, selective, irreversible and orally active semicarbazide-sensitive amine oxidase (SSAO; VAP-1) inhibitor with a K_i of 37 nM. PXS-4681A shows highly selectivity over related amine oxidases, ion channels, and seven-transmembrane domain receptors. PXS-4681A has anti-inflammatory effects .

HY-P9976A

Isatuximab (anti-CD38) 1 Publications Verification	CD38	Cancer
Isatuximab (anti-CD38) is a monoclonal antibody targeting the transmembrane receptor and extracellular enzyme CD38.Isatuximab induces tumor cell killing via fragment crystallizable (Fc)-dependent or Fc-independent mechanisms, including antibody-dependent cellular cytotoxicity (ADCC), antibody-dependent cellular phagocytosis (ADCP), and complement-dependent cytotoxicity (CDC) .

HY-103565A

AMN082 free base	mGluR	Neurological Disease
AMN082 free base, a selective, orally active, and brain penetrant mGluR7 agonist, directly activates receptor signaling via an allosteric site in the transmembrane domain. AMN082 free base potently inhibits cAMP accumulation and stimulates GTPγS binding (EC₅₀ values, 64-290 nM) at transfected mammalian cells expressing mGluR7. AMN082 free base shows selectivity over other mGluR subtypes and selected ionotropic glutamate receptors. Antidepressant effects .

HY-111751

JNJ-61432059 1 Publications Verification	iGluR	Neurological Disease
JNJ-61432059 is an oral active and selective negative modulator of AMPAR associated with trans-membrane AMPAR regulatory protein (TARP) γ-8, with a pIC₅₀ of 9.7 for GluA1/γ-8. Exhibits time- and dose-dependent AMPAR/γ-8 receptor occupancy in mouse hippocampus, resulting in robust seizure protection in corneal kindling and pentylenetetrazole (PTZ) anticonvulsant models .

HY-P9976

Isatuximab 1 Publications Verification	Apoptosis	Cancer
Isatuximab is a monoclonal antibody targeting the transmembrane receptor and ectoenzyme CD38, a protein highly expressed on hematological malignant cells, including those in multiple myeloma (MM). Isatuximab has antitumor activity via multiple biological mechanisms, including antibody-dependent cellular-mediated cytotoxicity, complement-dependent cytotoxicity, antibody-dependent cellular phagocytosis, and direct induction of apoptosis without crosslinking. Isatuximab also directly inhibits CD38 ectoenzyme activity, which is implicated in many cellular functions .

HY-P5357

SFNGGP-NH2	Protease Activated Receptor (PAR)	Others
SFNGGP-NH2 is a biological active peptide. (PAR-3 is a high-affinity thrombin receptor. PAR-3 mRNA is expressed in the cutaneous mast cells of humans. Protease-Activated Receptors (PARs) have been studied for their roles in itch and their itch-associated response through histamine-dependent/independent pathways have been reported. PAR-3 has been shown not to induce itching alone but possibly in conjunction with PAR-4. Co-expression of PAR-3 and PAR-4 enhances thrombin action suggesting that PAR-3 alone does not mediate transmembrane signaling but instead functions as a cofactor to activate PAR-4.)

Cat. No.	Product Name

HY-L150

Membrane Receptor-targeted Compound Library	4627 compounds
Membrane receptors, also known cell surface receptors or transmembrane receptors, are transmembrane proteins embedded into the plasma membrane which play an essential role in maintaining communication between the internal processes within the cell and various types of extracellular signals. They act in cell signaling by receiving (binding to) extracellular molecules, which are also called ligands. These extracellular molecules include hormones, cytokines, growth factors, neurotransmitters, lipophilic signaling molecules such as prostaglandins, and cell recognition molecules. There are three kinds of membrane receptors: ion channel-linked receptors, enzyme-linked receptors and G-protein-linked receptors. They play important roles in keeping human normal physiologic processes. GPCRs and ion channels are important drug targets in drug discovery. MCE provides a unique collection of 4627 compounds targeting a variety of membrane receptors. MCE Membrane reeptor-targeted Compound Library can be used for membrane receptor-focused screening and drug discovery.

Membrane Receptor-targeted Compound Library

4627 compounds

Membrane receptors, also known cell surface receptors or transmembrane receptors, are transmembrane proteins embedded into the plasma membrane which play an essential role in maintaining communication between the internal processes within the cell and various types of extracellular signals. They act in cell signaling by receiving (binding to) extracellular molecules, which are also called ligands. These extracellular molecules include hormones, cytokines, growth factors, neurotransmitters, lipophilic signaling molecules such as prostaglandins, and cell recognition molecules.

There are three kinds of membrane receptors: ion channel-linked receptors, enzyme-linked receptors and G-protein-linked receptors. They play important roles in keeping human normal physiologic processes. GPCRs and ion channels are important drug targets in drug discovery.

MCE provides a unique collection of 4627 compounds targeting a variety of membrane receptors. MCE Membrane reeptor-targeted Compound Library can be used for membrane receptor-focused screening and drug discovery.

HY-L016

Protein Tyrosine Kinase Compound Library	1055 compounds
Protein tyrosine kinases (PTKs) are key signaling molecules and important drug targets. Two classes of PTKs are present in cells: the transmembrane receptor PTKs (RTKs) and the nonreceptor PTKs. The RTK family includes the receptors for insulin and for many growth factors, such as EGFR, FGFR, PDGFR, VEGFR, and NGFR. RTKs are transmembrane glycoproteins that are activated by the binding of their ligands, and they transduce the extracellular signal to the cytoplasm by phosphorylating tyrosine residues on the receptors themselves (autophosphorylation) and on downstream signaling proteins. Their principal functions of PTKs involve the regulation of multicellular aspects of the organism. Cell to cell signals concerning growth, differentiation, adhesion, motility, and death are frequently transmitted through tyrosine kinases. In humans, tyrosine kinases have been demonstrated to play significant roles in the development of many disease states, including diabetes and cancers. MCE designs a unique collection of 1055 compounds that act as a useful tool for PTKs-related drug screening and disease research.

Protein Tyrosine Kinase Compound Library

1055 compounds

Protein tyrosine kinases (PTKs) are key signaling molecules and important drug targets. Two classes of PTKs are present in cells: the transmembrane receptor PTKs (RTKs) and the nonreceptor PTKs. The RTK family includes the receptors for insulin and for many growth factors, such as EGFR, FGFR, PDGFR, VEGFR, and NGFR. RTKs are transmembrane glycoproteins that are activated by the binding of their ligands, and they transduce the extracellular signal to the cytoplasm by phosphorylating tyrosine residues on the receptors themselves (autophosphorylation) and on downstream signaling proteins. Their principal functions of PTKs involve the regulation of multicellular aspects of the organism. Cell to cell signals concerning growth, differentiation, adhesion, motility, and death are frequently transmitted through tyrosine kinases. In humans, tyrosine kinases have been demonstrated to play significant roles in the development of many disease states, including diabetes and cancers.

MCE designs a unique collection of 1055 compounds that act as a useful tool for PTKs-related drug screening and disease research.

HY-L062

Neurotransmitter Receptor Compound Library	1785 compounds
Neurotransmitter (NT) receptors, also known as neuroreceptors, are a broadly diverse group of membrane proteins that bind neurotransmitters for neuronal signaling. There are two major types of neurotransmitter receptors: ionotropic and metabotropic. Ionotropic receptors are ligand-gated ion channels, meaning that the receptor protein includes both a neurotransmitter binding site and an ion channel. The binding of a neurotransmitter molecule (the ligand) to the binding site induces a conformational change in the receptor structure, which opens, or gates, the ion channel. The term “metabotropic receptors” is typically used to refer to transmembrane G-protein-coupled receptors. Metabotropic receptors trigger second messenger-mediated effects within cells after neurotransmitter binding. In some neurological diseases, the neurotransmitter receptor itself appears to be the target of the disease process. Many neuroactive drugs act by modifying neurotransmitter receptors. A better understanding of neurotransmitter receptor changes in disease may lead to improvements in therapy. MCE designs a unique collection of 1785 compounds targeting a variety of neurotransmitter receptors. MCE Neurotransmitter Receptor Compound Library is a useful tool for neurological diseases drug discovery.

Neurotransmitter Receptor Compound Library

1785 compounds

Neurotransmitter (NT) receptors, also known as neuroreceptors, are a broadly diverse group of membrane proteins that bind neurotransmitters for neuronal signaling. There are two major types of neurotransmitter receptors: ionotropic and metabotropic. Ionotropic receptors are ligand-gated ion channels, meaning that the receptor protein includes both a neurotransmitter binding site and an ion channel. The binding of a neurotransmitter molecule (the ligand) to the binding site induces a conformational change in the receptor structure, which opens, or gates, the ion channel. The term “metabotropic receptors” is typically used to refer to transmembrane G-protein-coupled receptors. Metabotropic receptors trigger second messenger-mediated effects within cells after neurotransmitter binding.

In some neurological diseases, the neurotransmitter receptor itself appears to be the target of the disease process. Many neuroactive drugs act by modifying neurotransmitter receptors. A better understanding of neurotransmitter receptor changes in disease may lead to improvements in therapy.

MCE designs a unique collection of 1785 compounds targeting a variety of neurotransmitter receptors. MCE Neurotransmitter Receptor Compound Library is a useful tool for neurological diseases drug discovery.

HY-L008

JAK/STAT Compound Library	423 compounds
The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is central to signaling by cytokine receptors, a superfamily of more than 30 transmembrane proteins that recognize specific cytokines, and is critical in blood formation and immune response. Canonical JAK/STAT signaling begins with the association of cytokines and their corresponding transmembrane receptors. Activated JAKs then phosphorylate latent STAT monomers, leading to dimerization, nuclear translocation, and DNA binding. In mammals, there are four JAKs (JAK1, JAK2, JAK3, TYK2) and seven STATs (STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b, STAT6). Since the JAK/STAT pathway plays a major role in many fundamental processes, such as apoptosis and inflammation, dysfunctional proteins in the pathway may lead to a number of diseases. For example, alterations in JAK/STAT signalling can result in cancer and diseases affecting the immune system, such as severe combined immunodeficiency disorder (SCID). MCE provides 423 compounds that can be used in the study of the JAK/STAT signaling pathway and related diseases.

JAK/STAT Compound Library

423 compounds

The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is central to signaling by cytokine receptors, a superfamily of more than 30 transmembrane proteins that recognize specific cytokines, and is critical in blood formation and immune response. Canonical JAK/STAT signaling begins with the association of cytokines and their corresponding transmembrane receptors. Activated JAKs then phosphorylate latent STAT monomers, leading to dimerization, nuclear translocation, and DNA binding. In mammals, there are four JAKs (JAK1, JAK2, JAK3, TYK2) and seven STATs (STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b, STAT6). Since the JAK/STAT pathway plays a major role in many fundamental processes, such as apoptosis and inflammation, dysfunctional proteins in the pathway may lead to a number of diseases. For example, alterations in JAK/STAT signalling can result in cancer and diseases affecting the immune system, such as severe combined immunodeficiency disorder (SCID).

MCE provides 423 compounds that can be used in the study of the JAK/STAT signaling pathway and related diseases.

Cat. No.	Product Name	Target	Research Area

HY-P0204A

Endothelin-3, human, mouse, rabbit, rat TFA 1 Publications Verification Endothelin 3 (Rat,Human) (TFA)	Endothelin Receptor	Cardiovascular Disease Neurological Disease
Endothelin-3, human, mouse, rabbit, rat TFA is a 21-amino acid vasoactive peptide that binds to G-protein-linked transmembrane receptors, ET-RA and ET-RB.

HY-P0207A

Endothelin-2 (49-69), human TFA Endothelin-2 (49-69) (human, canine) TFA; Human endothelin-2 TFA	Peptides	Cardiovascular Disease Cancer
Endothelin-2 (49-69), human (TFA) (Endothelin-2 (49-69) (human, canine) (TFA)) is a 21-amino acid vasoactive peptide that binds to G-protein-linked transmembrane receptors, ET-RA and ET-RB.

HY-P3496

Pep19-2.5	Pyroptosis	Inflammation/Immunology
Pep19-2.5 is an synthetic and antitoxin peptide, blocks the intracellular endotoxin signaling cascade. Pep19-2.5 inhibits signaling of lipopeptides (LP) and lipopolysaccharides (LPS) mediated by transmembrane and cytosolic pattern recognition receptors (PRRs). The signaling cascades lead to inflammation and cell pyroptosis .

HY-P0204

Endothelin-3, human, mouse, rabbit, rat Endothelin 3 (Rat,Human)	Peptides	Cardiovascular Disease Neurological Disease
Endothelin-3, human, mouse, rabbit, rat is a 21-amino acid vasoactive peptide that binds to G-protein-linked transmembrane receptors, ET-RA and ET-RB.

HY-P0207

Endothelin-2 (49-69), human Endothelin-2 (human, canine); Human endothelin-2	Peptides	Cardiovascular Disease Cancer
Endothelin-2 (49-69), human (Endothelin-2 (human, canine)) is a 21-amino acid vasoactive peptide that binds to G-protein-linked transmembrane receptors, ET-RA and ET-RB.

HY-P5357

SFNGGP-NH2	Protease Activated Receptor (PAR)	Others
SFNGGP-NH2 is a biological active peptide. (PAR-3 is a high-affinity thrombin receptor. PAR-3 mRNA is expressed in the cutaneous mast cells of humans. Protease-Activated Receptors (PARs) have been studied for their roles in itch and their itch-associated response through histamine-dependent/independent pathways have been reported. PAR-3 has been shown not to induce itching alone but possibly in conjunction with PAR-4. Co-expression of PAR-3 and PAR-4 enhances thrombin action suggesting that PAR-3 alone does not mediate transmembrane signaling but instead functions as a cofactor to activate PAR-4.)

Isatuximab (anti-CD38) 1 Publications Verification	CD38	Cancer
Isatuximab (anti-CD38) is a monoclonal antibody targeting the transmembrane receptor and extracellular enzyme CD38.Isatuximab induces tumor cell killing via fragment crystallizable (Fc)-dependent or Fc-independent mechanisms, including antibody-dependent cellular cytotoxicity (ADCC), antibody-dependent cellular phagocytosis (ADCP), and complement-dependent cytotoxicity (CDC) .

Isatuximab 1 Publications Verification	Apoptosis	Cancer
Isatuximab is a monoclonal antibody targeting the transmembrane receptor and ectoenzyme CD38, a protein highly expressed on hematological malignant cells, including those in multiple myeloma (MM). Isatuximab has antitumor activity via multiple biological mechanisms, including antibody-dependent cellular-mediated cytotoxicity, complement-dependent cytotoxicity, antibody-dependent cellular phagocytosis, and direct induction of apoptosis without crosslinking. Isatuximab also directly inhibits CD38 ectoenzyme activity, which is implicated in many cellular functions .

Species:	Human (22) Mouse (2)
Tag:	His (15) Avi (2) GST (1) MBP (1) Fc (7) Flag (2)
Source:	HEK293 (19) CHO (1) Sf9 insect cells (1) E. coli (3)

Cat. No.	Compare	Product Name	Species	Source

HY-P79214

	Frizzled-7 Protein, Human (CHO, hFc) Frizzled Class receptor 7; FzE3; Frizzled 7, Seven transmembrane Spanning receptor; Frizzled Family receptor 7; Frizzled-7	Human	CHO
	GIP Protein is a protein involved in the regulation of glucose homeostasis and insulin secretion. It plays a crucial role in modulating pancreatic beta-cell function and glucose metabolism. Dysregulation of GIP Protein has been associated with various diseases, including type 2 diabetes and obesity. Targeting GIP Protein may offer potential therapeutic interventions in these conditions by improving glucose regulation and insulin sensitivity. Frizzled-7 Protein, Human (CHO, hFc) is the recombinant human-derived Frizzled-7 protein, expressed by CHO , with C-hFc labeled tag. The total length of Frizzled-7 Protein, Human (CHO, hFc) is 153 a.a., with molecular weight of 46-60 kDa.

HY-P71263

	ROR2 Protein, Human (HEK293, His) Tyrosine-protein kinase transmembrane receptor ROR2; Neurotrophic tyrosine kinase, receptor-related 2; ROR2; NTRKR2	Human	HEK293
	The ROR2 protein is a tyrosine protein kinase receptor that plays a critical role in early chondrocyte formation and is essential for cartilage and growth plate development. Phosphorylated YWHAB induces osteogenesis and bone formation. ROR2 Protein, Human (HEK293, His) is the recombinant human-derived ROR2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of ROR2 Protein, Human (HEK293, His) is 370 a.a., with molecular weight of 50-60 kDa.

HY-P72410

	ROR1 Protein, Human (Biotinylated, HEK293, His-Avi) Inactive tyrosine-protein kinase transmembrane receptor ROR1; Neurotrophictyrosine kinase, receptor-related 1; NTRKR1	Human	HEK293
	ROR1 protein's minimal kinase activity in vitro suggests an improbable role as a tyrosine kinase in vivo. It serves as a receptor for WNT5A, activating NFkB signaling and potentially inhibiting WNT3A signaling. Notably, ROR1 plays a vital role in the inner ear, facilitating innervation of auditory hair cells by spiral ganglion neurons. ROR1 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived ROR1 protein, expressed by HEK293 , with C-Avi, C-6*His labeled tag. The total length of ROR1 Protein, Human (Biotinylated, HEK293, His-Avi) is 374 a.a., with molecular weight of 55-80 kDa.

HY-P70732

	ROR1 Protein, Human (HEK293, His) Inactive tyrosine-protein kinase transmembrane receptor ROR1; Neurotrophic tyrosine kinase, receptor-related 1; ROR1; NTRKR1	Human	HEK293
	ROR1 protein's minimal kinase activity in vitro suggests an improbable role as a tyrosine kinase in vivo. It serves as a receptor for WNT5A, activating NFkB signaling and potentially inhibiting WNT3A signaling. Notably, ROR1 plays a vital role in the inner ear, facilitating innervation of auditory hair cells by spiral ganglion neurons. ROR1 Protein, Human (HEK293, His) is the recombinant human-derived ROR1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of ROR1 Protein, Human (HEK293, His) is 374 a.a., with molecular weight of 60-80 kDa.

HY-P71263A

	ROR2 Protein, Human (HEK293, C-His) Tyrosine-protein kinase transmembrane receptor ROR2; Neurotrophic tyrosine kinase, receptor-related 2; ROR2; NTRKR2	Human	HEK293
	The ROR2 protein is a tyrosine protein kinase receptor that plays a critical role in early chondrocyte formation and is essential for cartilage and growth plate development. Phosphorylated YWHAB induces osteogenesis and bone formation. ROR2 Protein, Human (HEK293, C-His) is the recombinant human-derived ROR2 protein, expressed by HEK293 , with C-10*His labeled tag. The total length of ROR2 Protein, Human (HEK293, C-His) is 370 a.a., with molecular weight of ~55 kDa.

HY-P73390

	ROR1 Protein, Human (sf9, His) Inactive tyrosine-protein kinase transmembrane receptor ROR1; ROR1; NTRKR1	Human	Sf9 insect cells
	ROR1 protein's minimal kinase activity in vitro suggests an improbable role as a tyrosine kinase in vivo. It serves as a receptor for WNT5A, activating NFkB signaling and potentially inhibiting WNT3A signaling. Notably, ROR1 plays a vital role in the inner ear, facilitating innervation of auditory hair cells by spiral ganglion neurons. ROR1 Protein, Human (sf9, His) is the recombinant human-derived ROR1 protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of ROR1 Protein, Human (sf9, His) is 331 a.a., with molecular weight of 55-70 kDa.

HY-P77396

	IGFLR1 Protein, Human (HEK293, Fc) IGF-like family receptor 1; transmembrane protein 149; TMEM149; U2AF1L4	Human	HEK293
	IGFLR1 protein, a probable cell membrane receptor, exhibits specific affinity for IGF-like family proteins IGFL1 and IGFL3, with higher binding affinity compared to others. This selective interaction profile suggests a key role for IGFLR1 in mediating cellular responses to these ligands, emphasizing its significance in the intricate network of cellular signaling pathways. IGFLR1 Protein, Human (HEK293, Fc) is the recombinant human-derived IGFLR1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of IGFLR1 Protein, Human (HEK293, Fc) is 159 a.a., with molecular weight of ~58.9 & 47.6 kDa, respectively.

HY-P71370

	TMIGD2 Protein, Human (HEK293, His) transmembrane and immunoglobulin domain-containing protein 2; Immunoglobulin and proline-rich receptor 1; IGPR1; TMIGD2	Human	HEK293
	TMIGD2 is a multifaceted protein actively involved in cellular processes, including cell-cell interactions, migration, and angiogenesis. Its interaction with HHLA2 enhances T cell proliferation and cytokine production through AKT-dependent signaling during TCR-mediated activation. TMIGD2 Protein, Human (HEK293, His) is the recombinant human-derived TMIGD2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of TMIGD2 Protein, Human (HEK293, His) is 128 a.a., with molecular weight of ~30.0 kDa.

HY-P71379

	TRAT1 Protein, Human (His) T-Cell receptor-Associated transmembrane Adapter 1; T-Cell receptor-Interacting Molecule; TRIM; pp29/30; TRAT1; TCRIM; HSPC062	Human	E. coli
	TRAT1 protein stabilizes the T-cell antigen receptor (TCR)/CD3 complex on T-cell surfaces. As a homodimer linked by disulfide bonds, TRAT1 interacts with CD3Z, enhancing the structural integrity and function of the TCR/CD3 complex. Phosphorylated TRAT1 also engages with PIK3R1, indicating its role in signaling pathways related to T-cell activation and response. TRAT1 Protein, Human (His) is the recombinant human-derived TRAT1 protein, expressed by E. coli , with C-6*His labeled tag. The total length of TRAT1 Protein, Human (His) is 158 a.a., with molecular weight of ~30.0 kDa.

HY-P77249

	TMIGD2 Protein, Human (HEK293, Fc) transmembrane and immunoglobulin domain-containing protein 2; Immunoglobulin and proline-rich receptor 1; IGPR1; TMIGD2	Human	HEK293
	TMIGD2, a multifaceted protein, actively participates in cellular processes, including cell-cell interaction, migration, and angiogenesis. Its interaction with HHLA2 enhances T-cell proliferation and cytokine production through AKT-dependent signaling during TCR-mediated activation. TMIGD2 may engage in homophilic interactions, regulating cell-cell communication. Interactions with CACNB2, DST, MIA, and NCKIPSD indicate its involvement in diverse cellular pathways, emphasizing its versatile functions in essential activities. TMIGD2 Protein, Human (HEK293, Fc) is the recombinant human-derived TMIGD2 protein, expressed by HEK293, with C-hFc labeled tag. The total length of TMIGD2 Protein, Human (HEK293, Fc) is 150 a.a., with molecular weight of ~40.9 KDa.

HY-P72160

	CXCR4 Protein, Human (GST) C-X-C chemokine receptor type 4; CD184; CD184 antigen; Chemokine C X C motif; receptor 4; Chemokine CXC Motif receptor 4; CXC-R4; CXCR-4; CXCR4; CXCR4_HUMAN; D2S201E; FB22; Fusin; HM89; HSY3RR; LAP 3; LAP3; LCR1; LESTR; Leukocyte derived seven transmembrane domain receptor; Leukocyte-derived seven transmembrane domain receptor; Lipopolysaccharide associated protein 3; Neuropeptide Y receptor Y3; NPY3R; NPYR; NPYRL; NPYY3; NPYY3R; Probable G protein coupled receptor lcr1 homolog; SDF 1 receptor; SDF-1 receptor; SEVEN-transmembrane-SEGMENT receptor; Stromal cell derived factor 1 receptor; Stromal cell-derived factor 1 receptor; WHIM; WHIMS	Human	E. coli
	The CXCR4 protein functions as a receptor for the CXC chemokine CXCL12/SDF-1, triggering an increase in intracellular calcium ions and activation of MAPK1/MAPK3. It is actively involved in AKT signaling, which is critical for regulating cell migration, especially in wound healing. CXCR4 Protein, Human (GST) is the recombinant human-derived CXCR4 protein, expressed by E. coli , with N-GST labeled tag. The total length of CXCR4 Protein, Human (GST) is 50 a.a., with molecular weight of ~32.6 kDa.

HY-P71565

	FCRL6 Protein, Human (His) Fc receptor homolog 6; Fc receptor-like 6; Fc receptor-like protein 6; Fc receptor-like protein 7; FcR-like protein 6; FcRH6; FcRL6; FCRL6_HUMAN; FLJ16056; IFGP6; IgSF type I transmembrane receptor; leukocyte receptor	Human	E. coli
	FCRL6 Protein serves as a receptor for MHC class II, interacting with HLA-DR when specific beta chains are associated. Although independent stimulation of FCRL6 doesn't contribute to cytokine production or cytotoxic activities, it exhibits tyrosine-phosphorylated interactions with proteins like PTPN11, PTPN6, INPP5D, INPPL1, and GRB2. These associations suggest FCRL6's potential regulatory role in signaling pathways involving tyrosine phosphorylation events with various cellular proteins. FCRL6 Protein, Human (His) is the recombinant human-derived FCRL6 protein, expressed by E. coli, with N-His labeled tag. The total length of FCRL6 Protein, Human (His) is 288 a.a., with molecular weight of ~35.7 kDa.

HY-P702566

	TRPA1 Protein, Human (HEK293, FLAG) TRPA1; Transient receptor potential cation channel subfamily A member 1; Ankyrin-like with transmembrane domains protein 1; Transformation-sensitive protein p120; Wasabi receptor	Human	HEK293

HY-P77282

	VSTM1 Protein, Human (HEK293, Fc) V-set and transmembrane domain-containing protein 1; SIRL-1; Signal inhibitory receptor on leukocytes-1; VSTM1	Human	HEK293
	VSTM1 interacts with S100A10 protein, inducing the dimerization of ANXA2/p36. This suggests a regulatory role in protein phosphorylation, with ANXA2 monomer being the preferred target for tyrosine-specific kinase in vitro. The resulting heterotetramer comprises two light chains of S100A10/p11 and two heavy chains of ANXA2/p36. Furthermore, VSTM1 engages with SCN10A and TASOR, indicating its participation in diverse molecular interactions. VSTM1 Protein, Human (HEK293, Fc) is the recombinant human-derived VSTM1 protein, expressed by HEK293, with C-hFc labeled tag. The total length of VSTM1 Protein, Human (HEK293, Fc) is 135 a.a., with molecular weight of 50-60 kDa.

HY-P77240

	TMED1 Protein, Human (HEK293, His) transmembrane emp24 domain-containing protein 1; Interleukin-1 receptor-like 1 ligand; Tp24; IL1RL1L; IL1RL1LG	Human	HEK293
	TMED1 Protein potentially facilitates vesicular protein trafficking in the early secretory pathway, acting as a cargo receptor on the lumenal side for secretory cargo incorporation into transport vesicles. It's implicated in vesicle coat formation on the cytoplasmic side and positively influences IL-33-mediated IL-8 and IL-6 production by interacting with IL1RL1. Involved in modulating innate immune signaling via the cGAS-STING pathway, TMED1 forms homodimers and interacts with RNF26, particularly crucial for this modulation. TMED1 Protein, Human (HEK293, His) is the recombinant human-derived TMED1 protein, expressed by HEK293, with C-10*His labeled tag. The total length of TMED1 Protein, Human (HEK293, His) is 171 a.a., with molecular weight of ~28 kDa.

HY-P77241

	TMED1 Protein, Mouse (HEK293, Fc) transmembrane emp24 domain-containing protein 1; Interleukin-1 receptor-like 1 ligand; Tp24; IL1RL1L; IL1RL1LG	Mouse	HEK293
	TMED1, or Transmembrane p24 trafficking protein 1, is a member of the EMP24/GP25L family. TMED1 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived TMED1 protein, expressed by HEK293, with C-hFc labeled tag. The total length of TMED1 Protein, Mouse (HEK293, Fc) is 170 a.a., with molecular weight of ~46 KDa.

HY-P701382

	TRPA1 Protein, Human (HEK293, His, MBP, FLAG) TRPA1; Transient receptor potential cation channel subfamily A member 1; Ankyrin-like with transmembrane domains protein 1; Transformation-sensitive protein p120; Wasabi receptor	Human	HEK293
	The TRPA1 protein is a receptor-activated nonselective cation channel that is critical for pain detection and may affect cold sensation, oxygen sensing, cough reflex, itch, and inner ear function. It responds to inflammatory mediators and irritants such as allyl thiocyanate (AITC), cinnamic aldehyde, diallyl disulfide (DADS), and acrolein. TRPA1 Protein, Human (HEK293, His, MBP, FLAG) is the recombinant human-derived TRPA1 protein, expressed by HEK293 , with N-10*His, N-MBP, C-Flag labeled tag. The total length of TRPA1 Protein, Human (HEK293, His, MBP, FLAG) is 1118 a.a. .

HY-P71428

	VSTM1 Protein, Human (119a.a, HEK293, His) V-set and transmembrane domain-containing protein 1; SIRL-1; Signal inhibitory receptor on leukocytes-1; VSTM1	Human	HEK293
	VSTM1 interacts with S100A10 protein, inducing the dimerization of ANXA2/p36. This suggests a regulatory role in protein phosphorylation, with ANXA2 monomer being the preferred target for tyrosine-specific kinase in vitro. The resulting heterotetramer comprises two light chains of S100A10/p11 and two heavy chains of ANXA2/p36. Furthermore, VSTM1 engages with SCN10A and TASOR, indicating its participation in diverse molecular interactions. VSTM1 Protein, Human (119a.a, HEK293, His) is the recombinant human-derived VSTM1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of VSTM1 Protein, Human (119a.a, HEK293, His) is 119 a.a., with molecular weight of 25-35 kDa.

HY-P702258

	CXCR4-VLPs Protein, Human (HEK293, His) CXC-R4; CXCR-4; FB22; Fusin; HM89; LCR1; Leukocyte-derived seven transmembrane domain receptor; LESTR; Lipopolysaccharide-associated protein 3; LAP-3; LPS-associated protein 3; NPYRL; Stromal cell-derived factor 1 receptor; SDF-1 receptor; CD antigen CD184	Human	HEK293
	The CXCR4 protein functions as a receptor for the CXC chemokine CXCL12/SDF-1, triggering an increase in intracellular calcium ions and activation of MAPK1/MAPK3. It is actively involved in AKT signaling, which is critical for regulating cell migration, especially in wound healing. CXCR4-VLPs Protein, Human (HEK293, His) is the recombinant human-derived CXCR4-VLPs protein, expressed by HEK293 , with C-10*His labeled tag. The total length of CXCR4-VLPs Protein, Human (HEK293, His) is 352 a.a., with molecular weight of 41.5 kDa.

HY-P700454

	IGFLR1 Protein, Human (HEK293, C-His) IGFLR1; IGF-like family receptor 1; TMEM149, transmembrane protein 149 , U2(RNU2) small nuclear RNA auxiliary factor 1 like 4 , U2AF1L4; FLJ22573; transmembrane protein 149; U2 small nuclear RNA auxiliary factor 1-like 4; U2(RNU2) small nuclear RNA auxiliary factor 1-like 4; TMEM149; U2AF1L4	Human	HEK293
	IGFLR1 protein, a probable cell membrane receptor, exhibits specific affinity for IGF-like family proteins IGFL1 and IGFL3, with higher binding affinity compared to others. This selective interaction profile suggests a key role for IGFLR1 in mediating cellular responses to these ligands, emphasizing its significance in the intricate network of cellular signaling pathways. IGFLR1 Protein, Human (HEK293, C-His) is the recombinant human-derived IGFLR1 protein, expressed by HEK293, with C-6*His labeled tag. The total length of IGFLR1 Protein, Human (HEK293, C-His) is 141 a.a., with molecular weight of 17.4 kDa.

HY-P73309

	Neuropilin-1 Protein, Human (Biotinylated, HEK293, His-Avi, solution) Neuropilin-1, His; CD304; NRP1; NRPNP1; VEGF165R; BDCA4	Human	HEK293
	Neuropilin-1 Protein plays a significant role by binding to VEGF-165, potentially inhibiting its cellular binding and inducing apoptosis. This dual functionality suggests its role in regulating VEGF-mediated processes. Interactions with semaphorin family members highlight its versatile ligand-binding capability. Neuropilin-1's expression adversely affects blood vessel number and integrity, suggesting a potential role in angiogenesis. Its diverse interactions underscore its importance in orchestrating complex cellular processes and implications in angiogenesis and apoptotic pathways. Neuropilin-1 Protein, Human (Biotinylated, HEK293, His-Avi, solution) is the recombinant human-derived Neuropilin-1 protein, expressed by HEK293 , with C-Avi, C-His labeled tag and V179A mutation. The total length of Neuropilin-1 Protein, Human (Biotinylated, HEK293, His-Avi, solution) is 623 a.a., with molecular weight of ~73.1 kDa.

HY-P73310

	Neuropilin-1 Protein, Human (V179A, HEK293, Fc) Neuropilin-1, His; CD304; NRP1; NRPNP1; VEGF165R; BDCA4	Human	HEK293
	Neuropilin-1 Protein plays a significant role by binding to VEGF-165, potentially inhibiting its cellular binding and inducing apoptosis. This dual functionality suggests its role in regulating VEGF-mediated processes. Interactions with semaphorin family members highlight its versatile ligand-binding capability. Neuropilin-1's expression adversely affects blood vessel number and integrity, suggesting a potential role in angiogenesis. Its diverse interactions underscore its importance in orchestrating complex cellular processes and implications in angiogenesis and apoptotic pathways. Neuropilin-1 Protein, Human (V179A, HEK293, Fc) is the recombinant human-derived Neuropilin-1 protein, expressed by HEK293 , with C-hFc labeled tag and V179A mutation. The total length of Neuropilin-1 Protein, Human (V179A, HEK293, Fc) is 623 a.a., with molecular weight of ~107.4 kDa.

HY-P73311

	Neuropilin-1 Protein, Human (644a.a, HEK293, His) Neuropilin-1, His; CD304; NRP1; NRPNP1; VEGF165R; BDCA4	Human	HEK293
	Neuropilin-1 (NRP1) is one of two neuropilins which acts as a cell-surface receptor which is involved in the development of the cardiovascular system, angiogenesis, the formation of certain neuronal circuits, organogenesis outside the nervous system, cellular internalization and vascular leakage as well as mediates the chemorepulsant activity of semaphorins. NRP1 also binds many ligands and various types of co-receptors to affect cell survival, migration, and attraction. Neuropilin-1 Protein, Human (644a.a, HEK293, His) is the recombinant human-derived Neuropilin-1 protein, expressed by HEK293 , with C-His, C-6*His labeled tag. The total length of Neuropilin-1 Protein, Human (644a.a, HEK293, His) is 623 a.a., with molecular weight of ~90 kDa.

HY-P73312

	Neuropilin-1 Protein, Mouse (HEK293, Fc) Neuropilin-1, His; CD304; NRP1; NRPNP1; VEGF165R; BDCA4	Mouse	HEK293
	Neuropilin-1 protein is an important receptor critical for cardiovascular system development, angiogenesis, neuronal circuit formation, and non-nervous system organogenesis. It mediates the chemical pulse activity of signaling proteins, recognizes C-terminal regular motifs on ligands, and promotes cellular internalization and vascular leakage. Neuropilin-1 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived Neuropilin-1 protein, expressed by HEK293 , with C-mFc labeled tag. The total length of Neuropilin-1 Protein, Mouse (HEK293, Fc) is 856 a.a., with molecular weight of ~120 kDa.

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